diff --git a/.gitattributes b/.gitattributes
deleted file mode 100644
index 5e2def9..0000000
--- a/.gitattributes
+++ /dev/null
@@ -1,2 +0,0 @@
-db/** filter=lfs diff=lfs merge=lfs -text
-tests/** filter=lfs diff=lfs merge=lfs -text
diff --git a/.readthedocs.yaml b/.readthedocs.yaml
new file mode 100644
index 0000000..960c1e8
--- /dev/null
+++ b/.readthedocs.yaml
@@ -0,0 +1,16 @@
+version: 2
+
+build:
+  os: ubuntu-22.04
+  tools:
+    python: "3.10"
+
+sphinx:
+  configuration: docs/source/conf.py
+
+python:
+  install:
+    - method: pip
+      path: .
+      extra_requirements:
+        - docs
diff --git a/docs/source/installation.rst b/docs/source/installation.rst
index d7795de..73436b8 100644
--- a/docs/source/installation.rst
+++ b/docs/source/installation.rst
@@ -17,5 +17,5 @@ Installation from our GitHub repository
 
     git clone https://github.com/GoekeLab/xpore.git
     cd xpore
-    python setup.py install
+    pip install .
 
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..414e0a9
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,55 @@
+[build-system]
+requires = ["setuptools>=61.0"]
+build-backend = "setuptools.build_meta"
+
+
+[project]
+name = "xpore"
+authors = [{name = "Ploy N. Pratanwanich", email = "naruemon.p@chula.ac.th"}]
+maintainers = [
+	{name = "Ploy N. Pratanwanich", email = "naruemon.p@chula.ac.th"},
+]
+requires-python = ">=3.8"
+description = "xpore is a python package for Nanopore data analysis of differential RNA modifications."
+dependencies = [
+	"numpy>=1.18.0",
+	"pandas>=0.25.3",
+	"scipy>=1.4.1",
+	"PyYAML",
+	"h5py>=2.10.0",
+	"pyensembl>=1.8.5",
+	"ujson>=4.0.1"
+]
+readme = "README.md"
+license = {text = "MIT"}
+classifiers = [
+	# Trove classifiers
+	# (https://pypi.python.org/pypi?%3Aaction=list_classifiers)
+	"Development Status :: 1 - Planning",
+	"License :: OSI Approved :: MIT License",
+	"Programming Language :: Python",
+	"Programming Language :: Python :: 3.8",
+	"Topic :: Software Development :: Libraries",
+	"Topic :: Scientific/Engineering :: Bio-Informatics",
+	"Intended Audience :: Science/Research",
+]
+dynamic = ["version"]
+
+[project.optional-dependencies]
+test = ["pytest"]
+docs = ["sphinx", "sphinx_rtd_theme"]
+
+[project.urls]
+homepage = "https://github.com/GoekeLab/xpore"
+
+[project.scripts]
+xpore = "xpore.scripts.xpore:main"
+
+[tool.setuptools]
+include-package-data = true # set explicitly in case it changes in the future
+
+[tool.setuptools.packages.find]
+include = ["xpore*"]
+
+[tool.setuptools.dynamic]
+version = {attr = "xpore.__version__"}
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 294f341..0000000
--- a/setup.py
+++ /dev/null
@@ -1,46 +0,0 @@
-"""Setup for the xpore package."""
-
-from setuptools import setup,find_packages
-
-__pkg_name__ = 'xpore'
-
-
-with open('README.md') as f:
-    README = f.read()
-
-setup(
-    author="Ploy N. Pratanwanich",
-    maintainer_email="naruemon.p@chula.ac.th",
-    name=__pkg_name__,
-    license="MIT",
-    description='xpore is a python package for Nanopore data analysis of differential RNA modifications.',
-    version='v2.2',
-    long_description=README,
-    long_description_content_type='text/markdown',
-    url='https://github.com/GoekeLab/xpore',
-    packages=find_packages(),
-    include_package_data=True,
-    install_requires=[
-            'numpy>=1.18.0',
-            'pandas>=0.25.3',
-            'scipy>=1.4.1',
-            'PyYAML',
-            'h5py>=2.10.0',
-            'pyensembl>=1.8.5',
-            'ujson>=4.0.1'
-            ],
-    python_requires=">=3.8",
-    extras_require={'test': ['pytest']},
-    entry_points={'console_scripts': ["xpore={}.scripts.xpore:main".format(__pkg_name__)]},
-    classifiers=[
-        # Trove classifiers
-        # (https://pypi.python.org/pypi?%3Aaction=list_classifiers)
-        'Development Status :: 1 - Planning',
-        'License :: OSI Approved :: MIT License',
-        'Programming Language :: Python',
-        'Programming Language :: Python :: 3.8',
-        'Topic :: Software Development :: Libraries',
-        'Topic :: Scientific/Engineering :: Bio-Informatics',
-        'Intended Audience :: Science/Research',
-    ],
-)