diff --git a/CMake/ITKModuleDoxygen.cmake b/CMake/ITKModuleDoxygen.cmake
index 7a1ca952840..3af92802f76 100644
--- a/CMake/ITKModuleDoxygen.cmake
+++ b/CMake/ITKModuleDoxygen.cmake
@@ -3,6 +3,13 @@
 # ${_name}.dot file which defines the local dependency as graph
 # which will be then processed by dot
 
+# <source>/CMake in a build tree, the installed package directory otherwise.
+if(EXISTS "${ITK_CMAKE_DIR}/../Utilities/Doxygen/mcdoc.py")
+  set(ITK_MCDOC_SCRIPT "${ITK_CMAKE_DIR}/../Utilities/Doxygen/mcdoc.py")
+else()
+  set(ITK_MCDOC_SCRIPT "${ITK_CMAKE_DIR}/mcdoc.py")
+endif()
+
 macro(itk_module_doxygen _name)
   # _content defines the content of the ${_name}.dox file
   set(_content "/**\n")
@@ -49,7 +56,7 @@ macro(itk_module_doxygen _name)
         NAME ${_name}InDoxygenGroup
         COMMAND
           ${Python3_EXECUTABLE}
-          "${ITK_CMAKE_DIR}/../Utilities/Doxygen/mcdoc.py"
+          "${ITK_MCDOC_SCRIPT}"
           check
           ${_name}
           ${${_name}_SOURCE_DIR}/include
diff --git a/CMake/ITKModuleExternal.cmake b/CMake/ITKModuleExternal.cmake
index 2aa1f99c93c..6347832be2b 100644
--- a/CMake/ITKModuleExternal.cmake
+++ b/CMake/ITKModuleExternal.cmake
@@ -255,23 +255,24 @@ if(ITK_WRAPPING)
         "${CMAKE_CURRENT_SOURCE_DIR}/wrapping/CMakeLists.txt"
   )
     set(EXTERNAL_WRAP_ITK_PROJECT ON)
-    set(WRAP_ITK_CMAKE_DIR "${ITK_CMAKE_DIR}/../Wrapping")
-    include("${WRAP_ITK_CMAKE_DIR}/TypedefMacros.cmake")
-    # Build tree
+    # <source>/CMake in a build tree, the installed package directory otherwise.
     if(EXISTS "${ITK_CMAKE_DIR}/../Wrapping/CMakeLists.txt")
-      add_subdirectory(
-        "${ITK_CMAKE_DIR}/../Wrapping"
-        ${CMAKE_CURRENT_BINARY_DIR}/Wrapping
-      )
-      # Install tree
-    elseif(EXISTS"${ITK_CMAKE_DIR}/Wrapping/CMakeLists.txt")
-      add_subdirectory(
-        "${ITK_CMAKE_DIR}/Wrapping"
-        ${CMAKE_CURRENT_BINARY_DIR}/Wrapping
-      )
+      set(WRAP_ITK_CMAKE_DIR "${ITK_CMAKE_DIR}/../Wrapping")
+    elseif(EXISTS "${ITK_CMAKE_DIR}/Wrapping/CMakeLists.txt")
+      set(WRAP_ITK_CMAKE_DIR "${ITK_CMAKE_DIR}/Wrapping")
     else()
-      message(FATAL_ERROR "Could not find wrapping infrastructure.")
+      message(
+        FATAL_ERROR
+        "Could not find wrapping infrastructure at ${ITK_CMAKE_DIR}. To wrap a module against an installed ITK, that ITK must be reconfigured with ITK_INSTALL_WRAPPING_DEVELOPMENT_FILES=ON, then rebuilt and reinstalled."
+      )
     endif()
+    include("${WRAP_ITK_CMAKE_DIR}/TypedefMacros.cmake")
+    # Python registers the factories at import; the wrapping library must not.
+    set(ITK_WRAPPING_NO_FACTORY_REGISTER_MANAGER ON)
+    add_subdirectory(
+      "${WRAP_ITK_CMAKE_DIR}"
+      ${CMAKE_CURRENT_BINARY_DIR}/Wrapping
+    )
   endif()
 endif()
 # Create target to download data from the ITKData group.  This must come after
diff --git a/CMake/ITKModuleHeaderTest.cmake b/CMake/ITKModuleHeaderTest.cmake
index 22745f5c78b..d9570f7cd90 100644
--- a/CMake/ITKModuleHeaderTest.cmake
+++ b/CMake/ITKModuleHeaderTest.cmake
@@ -4,6 +4,16 @@
 # primary purpose of this test is to make sure there are not missing module
 # dependencies.
 
+# <source>/CMake in a build tree, the installed package directory otherwise.
+if(EXISTS "${ITK_CMAKE_DIR}/../Utilities/Maintenance/BuildHeaderTest.py")
+  set(
+    ITK_BUILD_HEADER_TEST_SCRIPT
+    "${ITK_CMAKE_DIR}/../Utilities/Maintenance/BuildHeaderTest.py"
+  )
+else()
+  set(ITK_BUILD_HEADER_TEST_SCRIPT "${ITK_CMAKE_DIR}/BuildHeaderTest.py")
+endif()
+
 # Improve performance of MSVC GUI, by reducing number of header tests.
 set(MAXIMUM_NUMBER_OF_HEADERS_default 35)
 if(MSVC)
@@ -114,8 +124,7 @@ macro(itk_module_headertest _name)
         OUTPUT
           ${_header_test_src}
         COMMAND
-          ${Python3_EXECUTABLE}
-          ${ITK_CMAKE_DIR}/../Utilities/Maintenance/BuildHeaderTest.py ${_name}
+          ${Python3_EXECUTABLE} ${ITK_BUILD_HEADER_TEST_SCRIPT} ${_name}
           ${${_name}_SOURCE_DIR} ${${_name}_BINARY_DIR}
           ${MAXIMUM_NUMBER_OF_HEADERS} ${_test_num}
       )
@@ -126,6 +135,10 @@ macro(itk_module_headertest _name)
           ${ITK_MODULE_${_name}_TARGETS_NAMESPACE}${_name}Module
           ${ITK_MODULE_${_name}_TARGETS_NAMESPACE}ITKKWSysModule
       )
+      # UseITK's register manager references every IO factory the ITK enables.
+      if(NOT ITK_SOURCE_DIR)
+        target_link_libraries(${_test_name} PRIVATE ${ITK_LIBRARIES})
+      endif()
 
       target_link_options(
         ${_test_name}
diff --git a/CMake/ITKModuleKWStyleTest.cmake b/CMake/ITKModuleKWStyleTest.cmake
index 69a5060303a..bc5abbca804 100644
--- a/CMake/ITKModuleKWStyleTest.cmake
+++ b/CMake/ITKModuleKWStyleTest.cmake
@@ -32,7 +32,11 @@ if(
   AND
     NOT
       CMAKE_CROSSCOMPILING
+  AND
+    EXISTS
+      "${ITK_CMAKE_DIR}/../Utilities/KWStyle/BuildKWStyle.cmake"
 )
+  # Only an ITK source tree carries BuildKWStyle.cmake; an install tree does not.
   include(${ITK_CMAKE_DIR}/../Utilities/KWStyle/BuildKWStyle.cmake)
 elseif(NOT KWSTYLE_FOUND)
   set(ITK_USE_KWSTYLE OFF)
diff --git a/CMake/ITKModuleTest.cmake b/CMake/ITKModuleTest.cmake
index 86aefd6c49b..720f4a4409a 100644
--- a/CMake/ITKModuleTest.cmake
+++ b/CMake/ITKModuleTest.cmake
@@ -87,6 +87,10 @@ EM_ASM(
       ${KIT_LIBS}
       ${ITKTestKernel_LIBRARIES}
   )
+  # UseITK's register manager references every IO factory the ITK enables.
+  if(NOT ITK_SOURCE_DIR)
+    target_link_libraries(${KIT}TestDriver PRIVATE ${ITK_LIBRARIES})
+  endif()
   target_link_options(
     ${KIT}TestDriver
     PRIVATE
diff --git a/CMakeLists.txt b/CMakeLists.txt
index 4a17ab6f239..508dce5fc8e 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -878,6 +878,27 @@ install(
     CMake/itkTransformIOFactoryRegisterManager.h.in
     CMake/itkMeshIOFactoryRegisterManager.h.in
     CMake/ITKInitializeCXXStandard.cmake
+    # The transitive closure of include(ITKModuleExternal).
+    CMake/ITKModuleExternal.cmake
+    CMake/ITKModuleMacros.cmake
+    CMake/ITKModuleTest.cmake
+    CMake/ITKModuleInfo.cmake.in
+    CMake/ITKSetPython3Vars.cmake
+    CMake/ITKInitializeBuildType.cmake
+    CMake/ITKWindowsUtf8.cmake
+    CMake/ITKExternalData.cmake
+    CMake/ITKDownloadSetup.cmake
+    CMake/ExternalData.cmake
+    CMake/ExternalData_config.cmake.in
+    CMake/WrappingConfigCommon.cmake
+    CMake/itkRemoveTestFiles.cmake
+    CMake/ITKModuleDoxygen.cmake
+    CMake/ITKModuleHeaderTest.cmake
+    CMake/ITKModuleKWStyleTest.cmake
+    CMake/ITKModuleCPPCheckTest.cmake
+    CMake/CppcheckTargets.cmake
+    Utilities/Maintenance/BuildHeaderTest.py
+    Utilities/Doxygen/mcdoc.py
   DESTINATION ${ITK_INSTALL_PACKAGE_DIR}
   COMPONENT Development
 )
diff --git a/Documentation/docs/contributing/module_workflows.md b/Documentation/docs/contributing/module_workflows.md
index e4bdf98c7cc..9e7ee5d20c8 100644
--- a/Documentation/docs/contributing/module_workflows.md
+++ b/Documentation/docs/contributing/module_workflows.md
@@ -36,6 +36,28 @@ jobs:
       pypi_password: ${{ secrets.pypi_password }}
 ```
 
+## Building an external module against an installed ITK
+
+An external module can be configured, built, and Python-wrapped against an
+installed ITK prefix rather than an ITK build tree. Point `ITK_DIR` at the
+installed package directory, for example
+`<prefix>/lib/cmake/ITK-6.0`, and configure the module as usual.
+
+Wrapping additionally requires the SWIG type indices and the wrapping CMake
+infrastructure, which ITK installs only on request because the payload is
+tens of megabytes. To make an installed prefix usable as a wrapping SDK, the
+ITK being installed must be configured with:
+
+```bash
+cmake -DITK_WRAP_PYTHON:BOOL=ON \
+      -DITK_INSTALL_WRAPPING_DEVELOPMENT_FILES:BOOL=ON <itk-source>
+```
+
+then rebuilt and reinstalled. Configuring a module with `ITK_WRAP_PYTHON=ON`
+against a prefix that lacks these files fails with "Could not find wrapping
+infrastructure"; the remedy is to reconfigure, rebuild, and reinstall the ITK
+the module points at, not to change anything in the module.
+
 ## Further Reading
 
 For more information visit README documentation at the [ITKRemoteModuleBuildTestPackageAction](https://github.com/InsightSoftwareConsortium/ITKRemoteModuleBuildTestPackageAction/blob/main/README.md#itkremotemodulebuildtestpackageaction) project.
diff --git a/Wrapping/CMakeLists.txt b/Wrapping/CMakeLists.txt
index 1f4d8c95cd3..c09bcd38aae 100644
--- a/Wrapping/CMakeLists.txt
+++ b/Wrapping/CMakeLists.txt
@@ -267,3 +267,57 @@ if(ITK_WRAP_PYTHON)
   unset(ITK_STUB_DIR CACHE)
   unset(ITK_PKL_DIR CACHE)
 endif()
+
+# Lands under the package directory, where an installed consumer's ITK_DIR already points.
+if(ITK_INSTALL_WRAPPING_DEVELOPMENT_FILES)
+  set(_itk_wrapping_install_dir "${ITK_INSTALL_PACKAGE_DIR}/Wrapping")
+
+  macro(_itk_install_wrapping_development _source_dir _destination)
+    install(
+      DIRECTORY
+        "${_source_dir}/"
+      DESTINATION "${_destination}"
+      COMPONENT ${WRAP_ITK_INSTALL_COMPONENT_IDENTIFIER}WrappingDevelopment
+      FILES_MATCHING
+      ${ARGN}
+    )
+  endmacro()
+
+  _itk_install_wrapping_development(
+    "${WrapITK_SOURCE_DIR}"
+    "${_itk_wrapping_install_dir}"
+    PATTERN
+    "*.cmake"
+    PATTERN
+    "CMakeLists.txt"
+    PATTERN
+    "*.i"
+    PATTERN
+    "*.in"
+    PATTERN
+    "*.py"
+    PATTERN
+    "*.h"
+    PATTERN
+    "images"
+      EXCLUDE
+    PATTERN
+    "Tests"
+      EXCLUDE
+  )
+
+  _itk_install_wrapping_development(
+    "${WRAP_ITK_TYPEDEFS_DIRECTORY}"
+    "${_itk_wrapping_install_dir}/Typedefs"
+    PATTERN
+    "*.i"
+    PATTERN
+    "*.idx"
+    PATTERN
+    "*.mdx"
+    PATTERN
+    "*.h"
+  )
+
+  unset(_itk_wrapping_install_dir)
+endif()
diff --git a/Wrapping/TypedefMacros.cmake b/Wrapping/TypedefMacros.cmake
index 4d034eab42d..71a74ba01e0 100644
--- a/Wrapping/TypedefMacros.cmake
+++ b/Wrapping/TypedefMacros.cmake
@@ -133,6 +133,15 @@ macro(itk_wrap_module library_name)
   set(WRAPPER_LIBRARY_NAME "${library_name}")
   message(STATUS "${WRAPPER_LIBRARY_NAME}: Creating module.")
 
+  # Drop the register managers the consumer tree's UseITK put on this directory.
+  if(ITK_WRAPPING_NO_FACTORY_REGISTER_MANAGER)
+    foreach(_factory_name ${ITK_FACTORY_LIST})
+      string(TOUPPER ${_factory_name} _factory_uc)
+      remove_definitions(-DITK_${_factory_uc}_FACTORY_REGISTER_MANAGER)
+    endforeach()
+    unset(_factory_uc)
+  endif()
+
   # Mark the current source dir for inclusion because it may contain header files.
   include_directories(BEFORE "${CMAKE_CURRENT_SOURCE_DIR}")
   include_directories(BEFORE ${WRAPPER_LIBRARY_INCLUDE_DIRECTORIES})
diff --git a/Wrapping/WrappingOptions.cmake b/Wrapping/WrappingOptions.cmake
index 8b1fd7d71a4..cd4ff6817fe 100644
--- a/Wrapping/WrappingOptions.cmake
+++ b/Wrapping/WrappingOptions.cmake
@@ -13,6 +13,16 @@ else()
   set(ITK_WRAPPING OFF CACHE INTERNAL "Build external languages support" FORCE)
 endif()
 
+# Opt-in: the SWIG type indices are tens of MB.
+cmake_dependent_option(
+  ITK_INSTALL_WRAPPING_DEVELOPMENT_FILES
+  "Install the wrapping infrastructure and SWIG type indices so that external modules can be wrapped against an installed ITK"
+  OFF
+  "ITK_WRAPPING"
+  OFF
+)
+mark_as_advanced(ITK_INSTALL_WRAPPING_DEVELOPMENT_FILES)
+
 cmake_dependent_option(
   ITK_PYTHON_RELEASE_GIL
   "Release Python Global Interpreter Lock (GIL) during ITK operations"
diff --git a/Wrapping/macro_files/itk_auto_load_submodules.cmake b/Wrapping/macro_files/itk_auto_load_submodules.cmake
index 4ca246ebc1e..32cd4af007d 100644
--- a/Wrapping/macro_files/itk_auto_load_submodules.cmake
+++ b/Wrapping/macro_files/itk_auto_load_submodules.cmake
@@ -105,6 +105,10 @@ function(generate_castxml_commandline_flags)
 
   # create the files used to pass the file to include to castxml
   set(include_dir_list ${WRAPPER_LIBRARY_INCLUDE_DIRECTORIES})
+  # From an install tree the dependency targets carry no ITK include dirs.
+  if(ITK_INCLUDE_DIRS)
+    list(APPEND include_dir_list ${ITK_INCLUDE_DIRS})
+  endif()
   list(REMOVE_DUPLICATES include_dir_list)
 
   # CONFIG_CASTXML_INC_CONTENTS - variable used for building contents to write with file(GENERATE)