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Weekly update for 2026/01/11
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‎consistency.html‎

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<div>
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<h1><a href="https://MoseleyBioinformaticsLab.github.io/mwFileStatusWebsite/" style="text-decoration:none;color:white;">Metabolomics Workbench File Validator</a></h1>
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<p>
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Last Updated: 2026-01-04 07:46:30.500461
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Last Updated: 2026-01-11 07:52:12.236825
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<h2>Statistics</h2>
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Number of Studies: 421<br>
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Number of Analyses: 597<br>
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Number of Studies: 422<br>
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Number of Analyses: 598<br>
2020
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<h3>Validation Statistics</h3>
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<a href="https://0.github.io/MoseleyBioinformaticsLab/validation_error" class="stats__grid__item orange">Validation Error</a>
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<div class="stats__grid__item">mwTab</div>
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<div class="stats__grid__item brightgreen">Consistent</div>
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</div> <br> <div class="grid header">
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<input type="checkbox" id="study_grid_item421" class="study_checkbox"/>
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<label for="study_grid_item421" href="#ST004507" class="study__grid__item">ST004507: 15N2 Glutamine Stable Isotope Tracing in SXO210, UTSW63, TS516, and HK157 - UT Southwestern Medical Center - McBrayer, Samuel</label>
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<div class="grid__description" style="height:10em;max-height:10">
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<div class="desc__grid">
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<div class="desc__grid__item">STUDY_TITLE</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">15N2 Glutamine Stable Isotope Tracing in SXO210, UTSW63, TS516, and HK157</div>
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<div class="desc__grid__item">STUDY_SUMMARY</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Background: In vivo stable isotope tracing is useful for natively surveying glioma metabolism but can be difficult to implement. Stable isotope tracing is tractable using in vitro glioma models, but most models lack nutrient conditions and cell populations relevant to human gliomas. This limits our ability to study glioma metabolism in the presence of an intact tumor microenvironment (TME) and immune-metabolic crosstalk. Methods: We optimized an in vitro stable isotope tracing approach for human glioma explants and glioma stem-like cell (GSC) lines that integrates human plasma-like medium (HPLM). UTSW63, TS516, and HK157 are human patient-derived glioma stem-like cells while SXO210 are glioblastoma organoid explants. We performed 15N2-glutamine tracing in GSC monocultures and human IDH-wildtype glioblastoma explants and developed an analytical framework to evaluate microenvironment-dependent metabolic features that distinguish them. We also conducted spatial transcriptomics to assess transcriptional correlates to metabolic activities. Results: HPLM culture preserved glioma explant viability and stemness while unmasking metabolic and immune programs suppressed by conventional culture conditions. Stable isotope tracing in HPLM revealed TME-dependent and TME-independent features of tumor metabolism. Tissue explants recapitulated tumor cell-intrinsic metabolic activities, such as synthesis of immunomodulatory purines. Unlike GSC monocultures, tissue explants captured tumor cell-extrinsic activities associated with stromal cell metabolism, as exemplified by astrocytic guanosine diphosphate mannose production in heterocellular explants. Finally, glioma explants displayed tumor subtype-specific metabolic reprogramming, including robust pyrimidine degradation in mesenchymal cells. Conclusions We present a tractable approach to assess glioma metabolism in vitro under physiologic nutrient levels and in the presence of an intact TME. This platform opens new avenues to interrogate glioma metabolism and its interplay with the immune microenvironment.</div>
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<div class="desc__grid__item">INSTITUTE</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">UT Southwestern Medical Center</div>
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<div class="desc__grid__item">DEPARTMENT</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Children's Research Institute</div>
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<div class="desc__grid__item">LABORATORY</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">McBrayer Laboratory</div>
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<div class="desc__grid__item">LAST_NAME</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">McBrayer</div>
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<div class="desc__grid__item">FIRST_NAME</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Samuel</div>
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<div class="desc__grid__item">ADDRESS</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">6000 Harry Hines Boulevard, NL11.110K, Dallas, TX 75235</div>
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<div class="desc__grid__item">EMAIL</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">samuel.mcbrayer@utsouthwestern.edu</div>
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<div class="desc__grid__item">PHONE</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">(214)-648-3730</div>
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</div>
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</div>
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</div>
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<div class="grid">
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<input type="checkbox" id="analysis_grid_item598" class="analysis_checkbox"/>
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<label for="analysis_grid_item598" href="#AN007556" class="analysis__grid__item orange">AN007556</label>
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<div>
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<span>
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<div class="shield">
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<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN007556/mwtab/txt" target="_blank">txt</a>
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</div>
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<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN007556_txt.log" target="_blank">Validation Error</a>
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<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN007556/mwtab/json" target="_blank">json</a>
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<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN007556/mwtab/comparison" target="_blank">comparison</a>
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</span>
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<br>
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<div class="desc__grid__item">ANALYSIS_ID</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN007556</div>
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