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MWvalidatorMWvalidator
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Weekly update for 2026/03/22
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‎consistency.html‎

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‎format.html‎

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<div>
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<h1><a href="https://MoseleyBioinformaticsLab.github.io/mwFileStatusWebsite/" style="text-decoration:none;color:white;">Metabolomics Workbench File Validator</a></h1>
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<p>
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Last Updated: 2026-03-15 08:20:49.762060
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Last Updated: 2026-03-22 08:13:55.318863
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</div>
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<div>
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<h2>Statistics</h2>
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<p>
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Number of Studies: 2592<br>
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Number of Analyses: 4050<br>
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Number of Studies: 2593<br>
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Number of Analyses: 4051<br>
2020
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<h3>Validation Statistics</h3>
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<div class="stats__grid">
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<div class="stats__grid__item">0</div>
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<a href="https://0.github.io/MoseleyBioinformaticsLab/validation_error" class="stats__grid__item orange">Validation Error</a>
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<a href="https://0.github.io/MoseleyBioinformaticsLab/parsing_error" class="stats__grid__item red">Parsing Error</a>
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<div class="stats__grid__item">mwTab</div>
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<div class="stats__grid__item">JSON</div>
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<a href="https://MoseleyBioinformaticsLab.github.io/mwFileStatusWebsite/value" class="stats__grid__item orange">Value Error</a>
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<h3>mwTab vs JSON Comparison Statistics</h3>
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<div class="stats__grid__item brightgreen">Consistent</div>
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<div class="stats__grid__item">1884</div>
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<div class="stats__grid__item orange">Inconsistent</div>
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<div class="stats__grid__item">2096</div>
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<div class="stats__grid__item">2097</div>
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<div class="stats__grid__item lightgrey">Not Checked</div>
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</div> <br> <div class="grid header">
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<input type="checkbox" id="study_grid_item2589" class="study_checkbox"/>
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<label for="study_grid_item2589" href="#ST004685" class="study__grid__item">ST004685: UPLC-MS/MS based fluxomics shows temporal oscillation of glucose metabolic flux is independent of feeding time (negative mode) - University of Pennsylvania - Malik, Dania</label>
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<label for="study_grid_item2589" href="#ST004684" class="study__grid__item">ST004684: BCAT1 promotes HCC metabolic reprogramming and survival through HIF-1α stabilization - University of Hong Kong - Kwan, Kenneth</label>
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<div class="grid__description" style="height:8em;max-height:8">
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<div class="desc__grid">
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<div class="desc__grid__item">STUDY_TITLE</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">BCAT1 promotes HCC metabolic reprogramming and survival through HIF-1α stabilization</div>
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<div class="desc__grid__item">STUDY_SUMMARY</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Hepatocellular carcinoma (HCC) is a highly lethal primary liver malignancy characterized by hypoxia, a common feature of solid tumors, particularly in HCC. Hypoxia-inducible factors (HIFs) play a pivotal role in mediating various cellular processes, such as metabolic adaptation, to support the survival of hypoxic cells. The cytosolic form of branched-chain amino transferase (BCAT1) is responsible for the reversible transamination reaction between branched-chain keto-amino acids (BCKAs) and branched-chain amino acids (BCAAs), facilitating the interconversion between α-ketoglutarate (α-KG) and glutamate. Interestingly, we found that in the context of HCC, BCAT1 consumes α-KG, thereby favoring the stabilization of HIF-1α through suppressing the α-KG-dependent prolyl hydroxylase (PHD). Knockdown (KD) or knockout (KO) of BCAT or BCAT inhibitor (ERG245) suppressed HIF-1 stability, as well as HIF-1 dependent transcriptomic and metabolic changes. Mass spectrometry (MS)-based isotopic carbon tracing showed that KD/KO or ERG 245 suppressed hypoxia/HIF-1-induced glycolytic flux. Interestingly, ERG245 effectively inhibited the proliferative output of hypoxic HCC cells and suppressed HCC growth. ERG245 also profoundly inhibited HCC growth in vitro and in vivo together with Sorafenib, a tyrosine kinase inhibitor (TKI) used in HCC by increasing the apoptotic cell death. Furthermore, we confirmed that the expressions of BCAT1 and the HIF-1α-targeted metabolic genes are positively correlated in human HCCs. Our findings unequivocally demonstrate that BCAT1 confers a growth advantage to HCC cells by stabilizing HIF-1α and orchestrating HIF-1α-mediated metabolic reprogramming. Consequently, targeting BCAT1 emerges as a promising therapeutic strategy for HCC patients.</div>
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<div class="desc__grid__item">INSTITUTE</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">University of Hong Kong</div>
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<div class="desc__grid__item">LAST_NAME</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Kwan</div>
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<div class="desc__grid__item">FIRST_NAME</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Kenneth</div>
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<div class="desc__grid__item">ADDRESS</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">QMH, Hong Kong, Hong Kong, 000000, China</div>
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<div class="desc__grid__item">EMAIL</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">p445kkl2@gmail.com</div>
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<div class="desc__grid__item">PHONE</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">92828773</div>
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</div>
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<div class="grid">
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<input type="checkbox" id="analysis_grid_item4047" class="analysis_checkbox"/>
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<label for="analysis_grid_item4047" href="#AN007911" class="analysis__grid__item orange">AN007911</label>
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<div class="shield">
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<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN007911/mwtab/txt" target="_blank">txt</a>
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</div>
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<div class="shieldRight orange">
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<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN007911_txt.log" target="_blank">Validation Error</a>
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<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN007911/mwtab/json" target="_blank">json</a>
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<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN007911/mwtab/comparison" target="_blank">comparison</a>
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<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN007911_comparison.log" target="_blank">Inconsistent</a>
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<br>
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<div class="desc__grid__item">ANALYSIS_ID</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN007911</div>
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<label for="study_grid_item2590" href="#ST004685" class="study__grid__item">ST004685: UPLC-MS/MS based fluxomics shows temporal oscillation of glucose metabolic flux is independent of feeding time (negative mode) - University of Pennsylvania - Malik, Dania</label>
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<label for="analysis_grid_item4047" href="#AN007912" class="analysis__grid__item orange">AN007912</label>
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<label for="study_grid_item2590" href="#ST004686" class="study__grid__item">ST004686: UPLC-MS/MS based fluxomics shows temporal oscillation of glucose metabolic flux is independent of feeding time (positive mode) - University of Pennsylvania - Malik, Dania</label>
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<label for="study_grid_item2591" href="#ST004686" class="study__grid__item">ST004686: UPLC-MS/MS based fluxomics shows temporal oscillation of glucose metabolic flux is independent of feeding time (positive mode) - University of Pennsylvania - Malik, Dania</label>
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<label for="study_grid_item2591" href="#ST004687" class="study__grid__item">ST004687: UPLC-MS/MS based fluxomics shows Temporal-gating of glucose processing is dependent on the circadian-clock - University of Pennsylvania - Malik, Dania</label>
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<label for="study_grid_item2592" href="#ST004687" class="study__grid__item">ST004687: UPLC-MS/MS based fluxomics shows Temporal-gating of glucose processing is dependent on the circadian-clock - University of Pennsylvania - Malik, Dania</label>
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