diff --git a/gff/MANIFEST.in b/gff/MANIFEST.in
index 8cbddded..8d88b2f4 100644
--- a/gff/MANIFEST.in
+++ b/gff/MANIFEST.in
@@ -1,4 +1,3 @@
 recursive-include BCBio *.py
-include distribute_setup.py
 include *.rst
 include LICENSE
diff --git a/gff/setup.py b/gff/setup.py
index 13cbd892..d22c5034 100644
--- a/gff/setup.py
+++ b/gff/setup.py
@@ -1,8 +1,6 @@
 #!/usr/bin/env python
 """Python setup file for Blue Collar Bioinformatics scripts and modules.
 """
-from distribute_setup import use_setuptools
-use_setuptools()
 from setuptools import setup, find_packages
 
 __version__ = "Undefined"