diff --git a/source/api_c/src/c_api.cc b/source/api_c/src/c_api.cc
index 1b92dad9ac..1786099110 100644
--- a/source/api_c/src/c_api.cc
+++ b/source/api_c/src/c_api.cc
@@ -730,6 +730,27 @@ inline void flatten_vector(std::vector<VALUETYPE>& onedv,
   }
 }
 
+namespace {
+
+constexpr char model_devi_nframes_error[] =
+    "DeePMD-kit Error: Model-deviation C APIs support exactly one frame.";
+
+bool validate_model_devi_nframes(DP_DeepBaseModelDevi* dp, const int nframes) {
+  if (nframes == 1) {
+    return true;
+  }
+
+  // These helpers serve extern "C" entry points, so an unsupported frame
+  // count must be reported through DP_*CheckOK instead of unwinding a C++
+  // exception into a C caller. Keep this validation before constructing any
+  // pointer ranges or accessing the model/neighbor list: invalid input must
+  // remain safe even when those arguments are otherwise unusable.
+  dp->exception = model_devi_nframes_error;
+  return false;
+}
+
+}  // namespace
+
 template <typename VALUETYPE>
 void DP_DeepPotModelDeviCompute_variant(
     DP_DeepPotModelDevi* dp,
@@ -746,8 +767,8 @@ void DP_DeepPotModelDeviCompute_variant(
     VALUETYPE* atomic_energy,
     VALUETYPE* atomic_virial,
     const VALUETYPE* charge_spin = nullptr) {
-  if (nframes > 1) {
-    throw std::runtime_error("nframes > 1 not supported yet");
+  if (!validate_model_devi_nframes(dp, nframes)) {
+    return;
   }
   // init C++ vectors from C arrays
   std::vector<VALUETYPE> coord_(coord, coord + natoms * 3);
@@ -857,8 +878,8 @@ void DP_DeepSpinModelDeviCompute_variant(DP_DeepSpinModelDevi* dp,
                                          VALUETYPE* virial,
                                          VALUETYPE* atomic_energy,
                                          VALUETYPE* atomic_virial) {
-  if (nframes > 1) {
-    throw std::runtime_error("nframes > 1 not supported yet");
+  if (!validate_model_devi_nframes(dp, nframes)) {
+    return;
   }
   // init C++ vectors from C arrays
   std::vector<VALUETYPE> coord_(coord, coord + natoms * 3);
@@ -972,8 +993,8 @@ void DP_DeepPotModelDeviComputeNList_variant(
     VALUETYPE* atomic_energy,
     VALUETYPE* atomic_virial,
     const VALUETYPE* charge_spin = nullptr) {
-  if (nframes > 1) {
-    throw std::runtime_error("nframes > 1 not supported yet");
+  if (!validate_model_devi_nframes(dp, nframes)) {
+    return;
   }
   // init C++ vectors from C arrays
   std::vector<VALUETYPE> coord_(coord, coord + natoms * 3);
@@ -1097,8 +1118,8 @@ void DP_DeepSpinModelDeviComputeNList_variant(DP_DeepSpinModelDevi* dp,
                                               VALUETYPE* virial,
                                               VALUETYPE* atomic_energy,
                                               VALUETYPE* atomic_virial) {
-  if (nframes > 1) {
-    throw std::runtime_error("nframes > 1 not supported yet");
+  if (!validate_model_devi_nframes(dp, nframes)) {
+    return;
   }
   // init C++ vectors from C arrays
   std::vector<VALUETYPE> coord_(coord, coord + natoms * 3);
diff --git a/source/api_c/tests/test_deepmd_exception.cc b/source/api_c/tests/test_deepmd_exception.cc
index c281b563f0..2c63868d5e 100644
--- a/source/api_c/tests/test_deepmd_exception.cc
+++ b/source/api_c/tests/test_deepmd_exception.cc
@@ -11,8 +11,32 @@
 #include <utility>
 #include <vector>
 
+#include "c_api.h"
+#include "c_api_internal.h"
 #include "deepmd.hpp"
 
+namespace {
+
+constexpr char model_devi_nframes_error[] =
+    "DeePMD-kit Error: Model-deviation C APIs support exactly one frame.";
+
+template <typename MODEL, typename INVOKE, typename CHECK_OK>
+void expect_model_devi_frame_error(const INVOKE& invoke,
+                                   const CHECK_OK& check_ok) {
+  // Use a fresh error carrier for every public entry point. Reusing a model
+  // would let a previous failure remain visible through CheckOK and could hide
+  // a wrapper that forgot to validate its own frame count.
+  MODEL model;
+  ASSERT_NO_THROW(invoke(&model));
+
+  const char* error = check_ok(&model);
+  ASSERT_NE(error, nullptr);
+  EXPECT_STREQ(error, model_devi_nframes_error);
+  DP_DeleteChar(error);
+}
+
+}  // namespace
+
 TEST(TestDeepmdException, deepmdexception) {
   std::string expected_error_message = "DeePMD-kit C API Error: unittest";
   try {
@@ -27,6 +51,147 @@ TEST(TestDeepmdException, deepmdexception_nofile) {
                deepmd::hpp::deepmd_exception);
 }
 
+TEST(TestModelDeviCAPIExceptionBoundary,
+     rejects_two_frames_across_all_multiframe_public_variants) {
+  constexpr int nframes = 2;
+  constexpr int natoms = 1;
+  const int atype[natoms] = {0};
+  const double coord[natoms * 3] = {0.0, 0.0, 0.0};
+  const float coordf[natoms * 3] = {0.0F, 0.0F, 0.0F};
+  const double spin[natoms * 3] = {0.0, 0.0, 0.0};
+  const float spinf[natoms * 3] = {0.0F, 0.0F, 0.0F};
+  const double charge_spin[1] = {0.0};
+  const float charge_spinf[1] = {0.0F};
+  DP_Nlist nlist;
+
+  const auto check_pot = [](DP_DeepPotModelDevi* model) {
+    return DP_DeepPotModelDeviCheckOK(model);
+  };
+  const auto check_spin = [](DP_DeepSpinModelDevi* model) {
+    return DP_DeepSpinModelDeviCheckOK(model);
+  };
+
+  // The four legacy model-deviation entry points have no nframes argument and
+  // always delegate with one frame. The twelve calls below cover every public
+  // entry point through which a caller can supply an unsupported frame count.
+  // Output and optional-parameter pointers may be null by contract. A default
+  // model and neighbor list deliberately keep this regression free of
+  // backend/model fixtures while verifying validation precedes model access.
+  expect_model_devi_frame_error<DP_DeepPotModelDevi>(
+      [&](DP_DeepPotModelDevi* model) {
+        DP_DeepPotModelDeviCompute2(model, nframes, natoms, coord, atype,
+                                    nullptr, nullptr, nullptr, nullptr, nullptr,
+                                    nullptr, nullptr, nullptr);
+      },
+      check_pot);
+  expect_model_devi_frame_error<DP_DeepPotModelDevi>(
+      [&](DP_DeepPotModelDevi* model) {
+        DP_DeepPotModelDeviComputef2(model, nframes, natoms, coordf, atype,
+                                     nullptr, nullptr, nullptr, nullptr,
+                                     nullptr, nullptr, nullptr, nullptr);
+      },
+      check_pot);
+  expect_model_devi_frame_error<DP_DeepSpinModelDevi>(
+      [&](DP_DeepSpinModelDevi* model) {
+        DP_DeepSpinModelDeviCompute2(
+            model, nframes, natoms, coord, spin, atype, nullptr, nullptr,
+            nullptr, nullptr, nullptr, nullptr, nullptr, nullptr, nullptr);
+      },
+      check_spin);
+  expect_model_devi_frame_error<DP_DeepSpinModelDevi>(
+      [&](DP_DeepSpinModelDevi* model) {
+        DP_DeepSpinModelDeviComputef2(
+            model, nframes, natoms, coordf, spinf, atype, nullptr, nullptr,
+            nullptr, nullptr, nullptr, nullptr, nullptr, nullptr, nullptr);
+      },
+      check_spin);
+
+  expect_model_devi_frame_error<DP_DeepPotModelDevi>(
+      [&](DP_DeepPotModelDevi* model) {
+        DP_DeepPotModelDeviComputeNList2(
+            model, nframes, natoms, coord, atype, nullptr, 0, &nlist, 0,
+            nullptr, nullptr, nullptr, nullptr, nullptr, nullptr, nullptr);
+      },
+      check_pot);
+  expect_model_devi_frame_error<DP_DeepPotModelDevi>(
+      [&](DP_DeepPotModelDevi* model) {
+        DP_DeepPotModelDeviComputeNListf2(
+            model, nframes, natoms, coordf, atype, nullptr, 0, &nlist, 0,
+            nullptr, nullptr, nullptr, nullptr, nullptr, nullptr, nullptr);
+      },
+      check_pot);
+  expect_model_devi_frame_error<DP_DeepSpinModelDevi>(
+      [&](DP_DeepSpinModelDevi* model) {
+        DP_DeepSpinModelDeviComputeNList2(model, nframes, natoms, coord, spin,
+                                          atype, nullptr, 0, &nlist, 0, nullptr,
+                                          nullptr, nullptr, nullptr, nullptr,
+                                          nullptr, nullptr, nullptr);
+      },
+      check_spin);
+  expect_model_devi_frame_error<DP_DeepSpinModelDevi>(
+      [&](DP_DeepSpinModelDevi* model) {
+        DP_DeepSpinModelDeviComputeNListf2(model, nframes, natoms, coordf,
+                                           spinf, atype, nullptr, 0, &nlist, 0,
+                                           nullptr, nullptr, nullptr, nullptr,
+                                           nullptr, nullptr, nullptr, nullptr);
+      },
+      check_spin);
+
+  expect_model_devi_frame_error<DP_DeepPotModelDevi>(
+      [&](DP_DeepPotModelDevi* model) {
+        DP_DeepPotModelDeviCompute3(
+            model, nframes, natoms, coord, atype, nullptr, nullptr, nullptr,
+            charge_spin, nullptr, nullptr, nullptr, nullptr, nullptr);
+      },
+      check_pot);
+  expect_model_devi_frame_error<DP_DeepPotModelDevi>(
+      [&](DP_DeepPotModelDevi* model) {
+        DP_DeepPotModelDeviComputef3(
+            model, nframes, natoms, coordf, atype, nullptr, nullptr, nullptr,
+            charge_spinf, nullptr, nullptr, nullptr, nullptr, nullptr);
+      },
+      check_pot);
+  expect_model_devi_frame_error<DP_DeepPotModelDevi>(
+      [&](DP_DeepPotModelDevi* model) {
+        DP_DeepPotModelDeviComputeNList3(model, nframes, natoms, coord, atype,
+                                         nullptr, 0, &nlist, 0, nullptr,
+                                         nullptr, charge_spin, nullptr, nullptr,
+                                         nullptr, nullptr, nullptr);
+      },
+      check_pot);
+  expect_model_devi_frame_error<DP_DeepPotModelDevi>(
+      [&](DP_DeepPotModelDevi* model) {
+        DP_DeepPotModelDeviComputeNListf3(model, nframes, natoms, coordf, atype,
+                                          nullptr, 0, &nlist, 0, nullptr,
+                                          nullptr, charge_spinf, nullptr,
+                                          nullptr, nullptr, nullptr, nullptr);
+      },
+      check_pot);
+}
+
+class TestModelDeviInvalidFrameCount : public ::testing::TestWithParam<int> {};
+
+TEST_P(TestModelDeviInvalidFrameCount, rejects_every_count_except_one) {
+  constexpr int natoms = 1;
+
+  expect_model_devi_frame_error<DP_DeepPotModelDevi>(
+      [&](DP_DeepPotModelDevi* model) {
+        // Required array pointers are deliberately unusable. The unsupported
+        // frame count must be rejected before pointer-range construction;
+        // otherwise zero/negative nframes could reach undefined pointer math.
+        DP_DeepPotModelDeviCompute2(model, GetParam(), natoms, nullptr, nullptr,
+                                    nullptr, nullptr, nullptr, nullptr, nullptr,
+                                    nullptr, nullptr, nullptr);
+      },
+      [](DP_DeepPotModelDevi* model) {
+        return DP_DeepPotModelDeviCheckOK(model);
+      });
+}
+
+INSTANTIATE_TEST_SUITE_P(UnsupportedFrameCounts,
+                         TestModelDeviInvalidFrameCount,
+                         ::testing::Values(-1, 0, 2));
+
 TEST(TestInputNlist, move_assignment_transfers_c_handle) {
   deepmd::hpp::InputNlist source;
   DP_Nlist* source_handle = source.nl;