diff --git a/mypy.ini b/mypy.ini
index e36c23ebbc8a..05d59c9ea7b0 100644
--- a/mypy.ini
+++ b/mypy.ini
@@ -14,7 +14,6 @@ exclude = (?x)(
   | (^|/)tests/unit/gapic/
   )
 
-
 # ==============================================================================
 # GLOBAL THIRD-PARTY & SHARED LIBRARY IGNORES
 # ==============================================================================
@@ -28,13 +27,7 @@ ignore_missing_imports = True
 [mypy-flask]
 ignore_missing_imports = True
 
-[mypy-google.auth.*]
-ignore_missing_imports = True
-
-[mypy-google.cloud.bigtable]
-ignore_missing_imports = True
-
-[mypy-google.cloud.pubsub]
+[mypy-google.api.*]
 ignore_missing_imports = True
 
 [mypy-google.colab]
@@ -61,6 +54,9 @@ ignore_missing_imports = True
 [mypy-grpc.*]
 ignore_missing_imports = True
 
+[mypy-grpc_status]
+ignore_missing_imports = True
+
 [mypy-ibis.*]
 ignore_missing_imports = True
 
@@ -86,8 +82,18 @@ ignore_missing_imports = True
 # ==============================================================================
 # PACKAGE-SPECIFIC OVERRIDES & EXCEPTIONS
 # ==============================================================================
+# --- bigframes ---
+[mypy-bigframes_vendored.*]
+ignore_errors = True
+
+# --- google-auth ---
+[mypy-google.auth.*]
+ignore_missing_imports = True
 
 # --- google-cloud-bigtable ---
+[mypy-google.cloud.bigtable]
+ignore_missing_imports = True
+
 [mypy-google.cloud.bigtable.*]
 ignore_errors = True
 
@@ -97,4 +103,26 @@ warn_unreachable = True
 disallow_any_generics = True
 ignore_errors = False
 
+[mypy-google.cloud.bigtable_admin.*]
+ignore_errors = True
+
+[mypy-google.cloud.bigtable_admin_v2.*]
+ignore_errors = True
+
+[mypy-google.cloud.bigtable_v2.*]
+ignore_errors = True
 
+# --- google-cloud-datastore ---
+[mypy-google.cloud.datastore.*]
+ignore_missing_imports = True
+
+[mypy-google.cloud.datastore._app_engine_key_pb2]
+ignore_errors = True
+
+# --- google-cloud-firestore ---
+[mypy-google.cloud.firestore.*]
+check_untyped_defs = True
+
+# --- google-cloud-pubsub ---
+[mypy-google.cloud.pubsub]
+ignore_missing_imports = True
diff --git a/packages/google-cloud-bigquery/mypy.ini b/packages/google-cloud-bigquery/mypy.ini
deleted file mode 100644
index a3cb5c292172..000000000000
--- a/packages/google-cloud-bigquery/mypy.ini
+++ /dev/null
@@ -1,3 +0,0 @@
-[mypy]
-python_version = 3.14
-namespace_packages = True
diff --git a/packages/google-cloud-bigquery/noxfile.py b/packages/google-cloud-bigquery/noxfile.py
index c1dd1692b744..d4accfea91a4 100644
--- a/packages/google-cloud-bigquery/noxfile.py
+++ b/packages/google-cloud-bigquery/noxfile.py
@@ -41,6 +41,17 @@
 ALL_PYTHON = ["3.10", "3.11", "3.12", "3.13", "3.14"]
 UNIT_TEST_PYTHON_VERSIONS = ALL_PYTHON
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 SYSTEM_TEST_PYTHON_VERSIONS = UNIT_TEST_PYTHON_VERSIONS
 
@@ -215,7 +226,13 @@ def mypy(session):
     )
     session.run("python", "-m", "pip", "freeze")
     with log_package_context(session):
-        session.run("mypy", "-p", "google", "--show-traceback")
+        session.run(
+            "mypy",
+            f"--config-file={MYPY_CONFIG_FILE}",
+            "-p",
+            "google",
+            "--show-traceback",
+        )
 
 
 @nox.session(python=SYSTEM_TEST_PYTHON_VERSIONS)