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Initial release of an Enterovirus A71 dataset - #467

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Initial release of an Enterovirus A71 dataset#467
nneune wants to merge 2 commits into
masterfrom
add-ev-a71

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@nneune

@nneune nneune commented Jul 23, 2026

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Enterovirus A71 dataset

This pull request introduces the initial release of a Nextclade dataset for Enterovirus A71 (EV-A71), designed for lineage classification, subgenotype assignment, mutation analysis, sequence quality control, and phylogenetic placement. The dataset uses a reconstructed ancestral sequence as the reference, which is genetically closer to currently circulating EV-A71 strains and supports more accurate analyses compared to historical prototypes.

The most important changes are:

Dataset Documentation and Metadata:

  • Added a comprehensive README.md describing the dataset's scope, features, clade definitions, reference types, and usage guidance, including authorship and contact information.
  • Added a CHANGELOG.md noting this as the initial release and providing a link to Nextclade dataset documentation.

Reference Data and Annotation:

  • Added reference.fasta containing the inferred ancestral EV-A71 sequence, which serves as the main reference for mutation calling and sequence alignment.
  • Added genome_annotation.gff3 with detailed genome feature annotations (e.g., CDS for VP4, VP2, VP3, VP1, and non-structural proteins) based on the BrCr prototype sequence.

Checklist

  • Send to ENPEN for testing

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