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27 changes: 26 additions & 1 deletion src/content/Competitive.tsx
Original file line number Diff line number Diff line change
@@ -1,5 +1,6 @@
import { A, AB, AD, B, D } from "../components/agent-symbols";
import StartExperiment from "../components/StartExperiment";
import Definition from "../components/shared/Definition";
import {
PLAY_BUTTON_ID,
RECORD_BUTTON_ID,
Expand Down Expand Up @@ -200,9 +201,33 @@ export const competitiveArray: PageContent[] = [
content:
"Congratulations, you’ve completed the Competitive Binding experiment!",
backButton: true,
// nextButton: true,
nextButton: true,
nextButtonText: "View examples",
section: Section.BonusContent,
layout: LayoutType.FullScreenOverlay,
},
{
title: "Real-world example: Hemoglobin, oxygen, and carbon monoxide",
content: (
<>
In this experiment, <D /> competed with <B /> for the same
binding site on <A />, which is exactly what happens with{" "}
<Definition term="hemoglobin" /> in your blood. Hemoglobin
normally binds <Definition term="oxygen" /> reversibly and
carries it to your body's tissues. But{" "}
<Definition term="carbon monoxide" /> binds that very same
site on hemoglobin far more tightly than oxygen does, so even

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Could be interesting to give a specific number, e.g. over 200x! I'm trying to find a specific source, Wikipedia says either 240x or 250x depending on the page https://en.wikipedia.org/wiki/Carboxyhemoglobin#Affinity_of_hemoglobin_for_carbon_monoxide

a small amount of carbon monoxide can occupy enough binding
sites to significantly reduce hemoglobin's ability to carry
oxygen - the same{" "}

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Suggested change
oxygen - the same{" "}
oxygen - the same type of{" "}

unless the binding strengths/affinities are similar

<Definition term="competitive inhibition" /> you just
measured with <D /> and <AB />.
</>
),
nextButton: true,
section: Section.BonusContent,
layout: LayoutType.PreComputedSimulation,
trajectoryUrl:
"https://aics-simularium-data.s3.us-east-2.amazonaws.com/trajectory/binding-affinity_hemoglobin-co.simularium",
},
];
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